Key result
Diabetic nephropathy was associated with significantly reduced carotid circumferential strain compared to healthy controls (4.94% vs 7.71%, p=0.000), which strongly correlated with impaired left ventricular global longitudinal strain (r=0.809).
Why the study?
To investigate the relationship between carotid artery elasticity and LV systolic function in patients with diabetic nephropathy using 2D-STE.
Does 2D speckle-tracking strain echocardiography reveal a correlation between carotid elasticity and left ventricular systolic function in patients with diabetic nephropathy?
Case-Control (n=220)
No
Does 2D speckle-tracking strain echocardiography reveal a correlation between carotid elasticity and left ventricular systolic function in patients with diabetic nephropathy?
2D speckle-tracking strain echocardiography demonstrates that reduced carotid elasticity strongly correlates with impaired left ventricular systolic function in patients with diabetic nephropathy, serving as an early marker of cardiovascular risk.
OBJECTIVE: To investigate the relationship between the elasticity of the carotid artery and the LV (left ventricle) systolic function in patients with diabetic nephropathy (DN) by using two-dimensional speckle-tracking strain echocardiography (2D-STE). METHODS: DN patients (n = 108) and control subjects (n = 112), all of whom underwent echocardiography and carotid ultrasound. Analysis of LV GLS (global longitudinal strain) from the apical two-chamber (2C), three-chamber (3C), and four-chamber (4C) views. Meanwhile, the circumferential strain (CS) of the carotid artery was obtained from the view of the short-axis right common carotid artery. The differences between the two groups were compared, and a correlation analysis between CS and GLS was performed. RESULTS: The 4CGLS, 2CGLS, 3CGLS, and CS of the DN group were significantly lower at significant levels in contrast to the control group (p < 0.05). There was a significantly positive correlation of CS with 4CGLS, 2CGLS, and 3CGLS in all subjects (r = 0.809, p = 0.000; r = 0.830, p = 0.000; r = 0.830, p = 0.000, respectively). CONCLUSION: 2D-STE is a relatively new technique for assessing the mechanical characteristics of the carotid artery in patients with DN. Reduced values of CS correlate with reduced LV systolic function as evaluated by strain measurements, which can predict the risk of systolic dysfunction of LV.
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Li et al. (2020) conducted a case-control in Diabetic nephropathy (n=220). Diabetic nephropathy vs. Healthy controls was evaluated on Circumferential strain (CS) of the carotid artery (p=0.000). Diabetic nephropathy was associated with significantly reduced carotid circumferential strain compared to healthy controls (4.94% vs 7.71%, p=0.000), which strongly correlated with impaired left ventricular global longitudinal strain (r=0.809).
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