Key result
Phospholamban mutants with hydrophobic substitutions at the Leu/Ile zipper region retained pentamer formation ability while providing equal or stronger inhibition of the Ca(2+)-pump.
Population
Cardiac sarcoplasmic reticulum model evaluating phospholamban mutants
Design
Preclinical
Authors
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Hypothesis-generating for PLN-targeted HF therapies; leaves open in vivo effects on cardiac Ca2+ handling.
The study proposes a modified model where the phospholamban monomer maintains contact with the Ca(2+)-pump around most of its circumference to exert inhibitory effects.
Cornea et al. (2000) studied this question. Leu/Ile zipper mutants of phospholamban was evaluated on Inhibition of the Ca(2+)-pump and pentameric stability. Phospholamban mutants with hydrophobic substitutions at the Leu/Ile zipper region retained pentamer formation ability while providing equal or stronger inhibition of the Ca(2+)-pump.
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