Human Performance: A Role for the ACE Genotype?

JONES, A., H.E. MONTGOMERY, and D.R. WOODS. Human performance: A role for the ACE genotype? Exerc. Sport Sci. Rev., Vol. 30, No. 4, pp. 184–190, 2002. The I allele of the angiotensin I-converting enzyme (ACE) gene is associated with lower ACE activity and endurance performance; an excess occurs in elite distance runners, rowers, and mountaineers, perhaps secondary to enhanced muscle efficiency. Conversely, the D allele is associated with training-related strength gain and elite power-oriented performance secondary to increased ACE and angiotensin II, a growth factor.