Competition binding assays revealed that 20 of 24 human rhinovirus serotypes share the same cellular receptor, while the remaining four attach to a different receptor.
The majority of human rhinovirus serotypes share a common cellular receptor for attachment.
Twenty-four human rhinovirus serotypes were grown and purified by centrifugation in metrizamide density gradients. These preparations had a lower buoyant density (1.24 g/cm3) and higher specific infectivities (1:24 to 1:240) than did rhinoviruses described previously (E. J. Stott and R. J. Killington, Annu. Rev. Microbiol. 26:503-524, 1972). Binding conditions in which the unique cellular receptors for virus attachment were saturated were determined for each serotype. Competition binding assays between pairs of serotypes allowed 20 of the 24 serotypes to be assigned to the same cellular receptor. The remaining four serotypes appeared to attach to a different cellular receptor. Since most serotypes were chosen for study at random, it seems likely that many of the yet unstudied rhinoviruses will share this common cellular receptor.
Abraham et al. (Wed,) conducted a other in Human rhinovirus. Competition binding assays was evaluated on Cellular receptor assignment. Competition binding assays revealed that 20 of 24 human rhinovirus serotypes share the same cellular receptor, while the remaining four attach to a different receptor.
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