Key result
Isolated adipocytes incorporated a much greater amount of radioactivity from labelled triglyceride-rich lipoproteins into lipids compared to epididymal fat pad pieces.
The study demonstrates that lipoprotein lipase may be more accessible to its substrate in isolated adipocytes than in fat pad pieces, and that glycerol released by lipoprotein glyceride hydrolysis can be partially incorporated into lipids by adipose tissue.
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Isolated adipocyte models may overestimate lipoprotein uptake; leaves open optimal in vitro systems for adipose lipid metabolism research.
Lasunción et al. (1981) studied this question. Isolated adipocytes vs. Epididymal fat pad pieces was evaluated on Incorporation of 3H-esterified fatty acids and 14C-glyceride glycerol into lipids. Isolated adipocytes incorporated a much greater amount of radioactivity from labelled triglyceride-rich lipoproteins into lipids compared to epididymal fat pad pieces.
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