Key result
Cloning and characterization of the Drosophila NOS gene (dNOS) revealed a 152 kDa protein with 43% identity to rat neuronal NOS and Ca2+/calmodulin-dependent activity.
Population
Drosophila model and cell culture
Design
Preclinical
Authors
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No immediate clinical implications; extends invertebrate models for NO signaling research.
The cloning and characterization of Drosophila NOS demonstrates remarkable structural and functional conservation of nitric oxide synthase between vertebrates and invertebrates.
Regulski et al. (1995) studied this question. dNOS cloning and characterization was evaluated on Molecular and biochemical characterization of dNOS. Cloning and characterization of the Drosophila NOS gene (dNOS) revealed a 152 kDa protein with 43% identity to rat neuronal NOS and Ca2+/calmodulin-dependent activity.
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