Key result
Two-wavelength intravascular photoacoustic imaging at 1718 and 1734 nm successfully detected and differentiated between plaque lipids and peri-adventitial fat in human coronary arteries ex vivo.
Why the study?
Can two-wavelength intravascular photoacoustic (IVPA) imaging detect and differentiate plaque lipids from peri-adventitial fat in human coronary arteries ex vivo?
Can two-wavelength intravascular photoacoustic (IVPA) imaging detect and differentiate plaque lipids from peri-adventitial fat in human coronary arteries ex vivo?
Two-wavelength IVPA imaging can successfully identify and differentiate atherosclerotic plaque lipids from peri-adventitial fat ex vivo, potentially enabling rapid in vivo data acquisition.
Ex vivo lipid differentiation feasible with two-wavelength IVPA; leaves open in vivo translation and clinical utility.
The lipid content in plaques is an important marker for identifying atherosclerotic lesions and disease states. Intravascular photoacoustic (IVPA) imaging can be used to visualize lipids in the artery. In this study, we further investigated lipid detection in the 1.7-µm spectral range. By exploiting the relative difference between the IVPA signal strengths at 1718 and 1734 nm, we could successfully detect and differentiate between the plaque lipids and peri-adventitial fat in human coronary arteries ex vivo. Our study demonstrates that IVPA imaging can positively identify atherosclerotic plaques using only two wavelengths, which could enable rapid data acquisition in vivo.
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Wu et al. (2015) studied Atherosclerotic plaques. Two-wavelength intravascular photoacoustic (IVPA) imaging (1718 and 1734 nm) was evaluated on Detection and differentiation between plaque lipids and peri-adventitial fat. Two-wavelength intravascular photoacoustic imaging at 1718 and 1734 nm successfully detected and differentiated between plaque lipids and peri-adventitial fat in human coronary arteries ex vivo.
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