Key result
Renal sympathetic denervation combined with CPAP significantly reduced the apnea/hypopnea index to 3.6 events/hour compared to 12.5 events/hour with CPAP alone in patients with sleep apnea.
Cohort (n=36)
Open-label
None
No
Answers are grounded in this paper and cite their sources.
May support adjunctive RSD in OSA with paroxysmal AF; hypothesis-generating and requires randomized trials before practice change.
Objective: Obstructive sleep apnea (OSA) is independently associated with atrial fibrillation (AF). We hypothesized that renal sympathetic denervation (RSD) could decrease the occurrence of AF and apnea/hypopnea index (AHI) in patients with controlled hypertension and OSA. We aimed to compare the impact of continuous positive airway pressure (CPAP) and CPAP+RSD in such patients.
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Kiuchi et al. (2016) conducted a cohort in Controlled hypertension, severe obstructive sleep apnea, and paroxysmal atrial fibrillation (n=36). Renal sympathetic denervation (RSD) + CPAP vs. CPAP alone was evaluated on Decrease in apnea/hypopnea index (AHI) at 6 months (p=0.0037). Renal sympathetic denervation combined with CPAP significantly reduced the apnea/hypopnea index to 3.6 events/hour compared to 12.5 events/hour with CPAP alone in patients with sleep apnea.
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