Key result
Atrial natriuretic factor infusion significantly attenuated the metoclopramide-induced rise in plasma aldosterone to 130% and 110% of baseline (P<0.05 and P<0.01), compared to 170% with placebo.
Why the study?
Does atrial natriuretic factor inhibit metoclopramide-stimulated aldosterone release in normal male volunteers?
RCT (n=8)
randomised
Does atrial natriuretic factor inhibit metoclopramide-stimulated aldosterone release in normal male volunteers?
Atrial natriuretic factor non-selectively inhibits aldosterone release, including that stimulated by metoclopramide, in normal human subjects.
Answers are grounded in this paper and cite their sources.
ANF inhibits metoclopramide-stimulated aldosterone release in healthy volunteers; extends evidence for its non-selective suppressive effects on mineralocorticoid secretion.
Atrial natriuretic factor (ANF) has an inhibitory effect on angiotensin II and ACTH stimulated aldosterone secretion in man. The selectivity of this aldosterone suppressing effect of ANF is unclear in man. The present study investigated the effect of ANF on the increase in plasma aldosterone due to metoclopramide in man. 2. Eight normal male volunteers were studied on three occasions. Metoclopramide (10 mg slow i.v.) was given on all study days and each volunteer was randomised to receive 45 min infusion of either 5% D-glucose (placebo) or ANF (99-126) 3 or 15 pmol kg-1 min-1. 3. Metoclopramide increased plasma aldosterone to approximately 170% of baseline levels (P less than 0.01). Concomitant infusion of ANF 3 pmol kg-1 min-1 and 15 pmol kg-1 min-1 significantly attenuated this rise in plasma aldosterone to approximately 130% (P less than 0.05) and 110% (P less than 0.01) of baseline values respectively. 4. It is suggested, in the light of previous findings, that the inhibitory effect of ANF represents a non-selective action of ANF on aldosterone release.
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Lang et al. (1991) conducted an RCT in Healthy volunteers (n=8). Atrial natriuretic factor (ANF) vs. 5% D-glucose (placebo) was evaluated on Plasma aldosterone levels as a percentage of baseline (p=<0.01). Atrial natriuretic factor infusion significantly attenuated the metoclopramide-induced rise in plasma aldosterone to 130% and 110% of baseline (P<0.05 and P<0.01), compared to 170% with placebo.
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