Key result
Ftorafur and 5-fluorouracil caused positive inotropic and chronotropic effects in isolated canine sinoatrial nodes, likely through direct action.
Why the study?
Do ftorafur and 5-fluorouracil induce inotropic and chronotropic effects in the canine sinoatrial node?
Population
Isolated sinoatrial node and atrial preparations obtained from canine puppies
Comparison
Ftorafur and 5-fluorouracil (5-FU) injection vs Solvent of 5-FU; presence of pindolol…
Design
Preclinical
Authors
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May warrant cardiac monitoring in patients on these agents; leaves open translation to human sinoatrial node function.
Do ftorafur and 5-fluorouracil induce inotropic and chronotropic effects in the canine sinoatrial node?
Ftorafur and 5-fluorouracil induce positive inotropic and chronotropic effects on the canine sinoatrial node, likely through direct action rather than adrenergic or calcium channel mechanisms.
Satoh et al. (1983) studied this question. Ftorafur and 5-fluorouracil vs. Solvent of 5-FU was evaluated on Inotropic and chronotropic effects. Ftorafur and 5-fluorouracil caused positive inotropic and chronotropic effects in isolated canine sinoatrial nodes, likely through direct action.
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