Why the study?
What are the cardiac and hemodynamic effects of piretanide compared to furosemide in anesthetized dogs and isolated atria?
Population
Intact anesthetized dogs and isolated atrial muscle perfused with heparinized arterial blood from a donor dog
Comparison
Piretanide (intravenous and intraarterial) vs Furosemide and propranolol
Design
Preclinical
Authors
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Piretanide's effects in dogs warrant no clinical extrapolation; leaves open whether direct cardiac actions differ from furosemide in humans.
What are the cardiac and hemodynamic effects of piretanide compared to furosemide in anesthetized dogs and isolated atria?
Piretanide exerts dose-dependent depressor effects in intact dogs and direct negative chronotropic and inotropic effects at high doses, differing from furosemide at standard doses.
Chiba et al. (1987) studied this question.
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