Key result
Furosemide and piretanide similarly reduce cardiac output and raise systemic vascular resistance post-MI.
Why the study?
The comparative hemodynamic effects of furosemide and piretanide in normovolemic patients recovering from myocardial infarction were not well characterized.
Does furosemide compared to piretanide alter pulmonary hemodynamics in normovolemic patients recovering from uncomplicated myocardial infarctions?
RCT (n=20)
Double-blind
Does furosemide compared to piretanide alter pulmonary hemodynamics in normovolemic patients recovering from uncomplicated myocardial infarctions?
Furosemide and piretanide have comparable hemodynamic effects, increasing venous compliance in normovolemic patients post-myocardial infarction.
Answers are grounded in this paper and cite their sources.
May warrant caution with these diuretics in early post-MI recovery; leaves open effects on clinical outcomes.
The effects of furosemide and piretanide (Hoe 118) on the pulmonary hemodynamics in 20 patients recovering from uncomplicated myocardial infarctions were compared in a double-blind study. The diuretic effects and half-lives of the two drugs were not significantly different, so that their hemodynamic actions could be compared directly. Both drugs progressively reduced cardiac output and pressures in the pulmonary circulation, whereas systemic vascular resistance increased significantly. Both drugs slightly increased pulmonary blood volume but not significantly. Total blood volume decreased less rapidly than cardiac output, so that the ratio of cardiac output to total blood volume decreased with time. We conclude that both drugs increase venous compliance in normovolemic subjects and probably increase the compliance of pulmonary vessels.
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Valette et al. (1980) conducted an RCT in Uncomplicated myocardial infarction (n=20). Furosemide vs. Piretanide was evaluated on Pulmonary hemodynamics (cardiac output, pulmonary pressures, systemic vascular resistance). Furosemide and piretanide both progressively reduced cardiac output and pulmonary pressures, and significantly increased systemic vascular resistance in patients recovering from uncomplicated MI.
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