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January 1, 1975The Japanese Journal of PharmacologyOpen Access

Comparison of the Effects of Norepinephrine and Acetylcholine Between Intraarterial and Extravascular Administration to the Isolated, Blood-Perfused Canine Atrium

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Why the study?

Does intraarterial administration of acetylcholine and norepinephrine produce different effects on atrial contractility and pacemaker activity compared to extravascular administration in isolated canine atria?

Population

Isolated, blood-perfused canine atrium preparations suspended in a blood-filled bath at 37 degrees C with a…

Comparison

Intraarterial injection of acetylcholine and… vs Direct administration of acetylcholine and…

Design

Preclinical

Authors

SCShigetoshi ChibaMount Sinai HospitalYYYouichi YabuuchiOtsuka (Japan)KHKoroku HashimotoFood and Drug Safety Center

Discussion

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Implication

Route-dependent potency in isolated atria requires careful model interpretation; leaves open relevance to intact hearts or clinical use.

Structured PICO

Does intraarterial administration of acetylcholine and norepinephrine produce different effects on atrial contractility and pacemaker activity compared to extravascular administration in isolated canine atria?

P
Population
Isolated, blood-perfused canine atrium preparations suspended in a blood-filled bath at 37 degrees C with a support dog
I
Intervention
Intraarterial injection of acetylcholine (ACh) and norepinephrine into the cannulated sinus node artery
C
Comparator
Direct administration of acetylcholine (ACh) and norepinephrine into the bath (extravascular administration)
O
Outcome
Atrial contractility (developed tension) and pacemaker activitysurrogate

Intraarterial administration of acetylcholine and norepinephrine yields a vastly greater contractile response in isolated canine atria compared to extravascular bath administration.

Cite This Study

Chiba et al. (1975) studied this question.

synapsesocial.com/papers/6a90a148f5c79ce9992dc5d5https://doi.org/10.1254/jjp.25.433
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