June 1, 1975American Journal of Physiology-Legacy Content

Acetylcholine and norepinephrine interactions on cardiac lipids and hemodynamics

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Population

Open-chest dogs anesthetized with sodium pentobarbital

Comparison

Intracoronary administration of acetylcholine… vs Control levels (baseline)

Design

Preclinical

Authors

VGVV Glaviano JGJack GoldbergUniversity of Washington MPM. T. PindokLoyola University Chicago

Discussion

Member takes

Implication

Acetylcholine may antagonize norepinephrine effects on myocardial metabolism in animals; leaves open translation to human cardiac physiology.

Structured PICO

Population

Open-chest dogs anesthetized with sodium pentobarbital

Intervention

Intracoronary administration of acetylcholine (ACh, 5 x 10^-5M) and norepinephrine (NE, 2.4 x 10^-6M), alone and in combination

Comparator

Control levels (baseline)

Outcome

Myocardial O2 extraction ratio and uptake, coronary flow, hemodynamics, adenylate cyclase activity, hormone-sensitive lipase activity, and free fatty acid uptakesurrogate

Acetylcholine antagonizes norepinephrine-stimulated myocardial lipid metabolism via the adenylate cyclase system.

Cite This Study

Glaviano et al. (1975) studied this question.

synapsesocial.com/papers/6a8fdbf286bcbf2f678c8b10 https://doi.org/10.1152/ajplegacy.1975.228.6.1678

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Implication

Acetylcholine may antagonize norepinephrine effects on myocardial metabolism in animals; leaves open translation to human cardiac physiology.

Acetylcholine and norepinephrine interactions on cardiac lipids and hemodynamics

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Acetylcholine and norepinephrine interactions on cardiac lipids and hemodynamics

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider