What question did this study set out to answer?

To determine the direct and indirect effects of norepinephrine infusion on myocardial free fatty acid uptake, extraction, and oxidation.

April 1, 1965Experimental Biology and Medicine

Effect of Norepinephrine on Myocardial Free Fatty Acid Uptake and Oxidation,

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Why the study?

Does norepinephrine alter myocardial free fatty acid uptake and oxidation in an anesthetized dog model?

Population

Intact anesthetized dog model

Comparison

Intravenous infusion of norepinephrine alongside… vs Initial intravenous infusion of labeled palmitic…

Design

Preclinical

Follow-up

90 minutes interval between infusions

Authors

MGM. GoldHahnemann University Hospital HAH. J. AttarHahnemann University Hospital JSJ. J. SpitzerSemmelweis University

Discussion

Member takes

Implication

Norepinephrine may indirectly modulate myocardial FFA oxidation in dogs; hypothesis-generating for human cardiac metabolism and should not change practice.

Key Points

To determine the direct and indirect effects of norepinephrine infusion on myocardial free fatty acid uptake, extraction, and oxidation.
Administered repeated intravenous infusions of labeled palmitic acid at 90-minute intervals in intact anesthetized dogs.
Infused norepinephrine at doses of 0.2 or 0.4 µg/kg/min during the second experimental period, with or without preceding nicotinic acid administration.
High-dose norepinephrine increased arterial free fatty acid concentrations, coronary sinus-arterial differences, and overall myocardial free fatty acid uptake.
Norepinephrine infusion decreased the specific activity of arterial free fatty acids, the myocardial extraction ratio, and the myocardial respiratory quotient.
Pretreatment with nicotinic acid abolished these metabolic alterations, demonstrating that norepinephrine influences myocardial free fatty acid oxidation indirectly by stimulating systemic free fatty acid mobilization.

Structured PICO

Does norepinephrine alter myocardial free fatty acid uptake and oxidation in an anesthetized dog model?

Population

Intact anesthetized dog model

Intervention

Intravenous infusion of norepinephrine (0.2 or 0.4 μg/kg/min) alongside labeled palmitic acid

Comparator

Initial intravenous infusion of labeled palmitic acid alone (within-subject control)

Outcome

Myocardial free fatty acid (FFA) uptake and oxidation parameters (arterial FFA, CS-A difference, extraction ratio, myocardial R.Q.)surrogate

Norepinephrine indirectly influences myocardial free fatty acid oxidation by mobilizing FFA and elevating its arterial levels.

Cite This Study

Gold et al. (1965) studied this question.

synapsesocial.com/papers/6a90fe9e504d7cdc493e8364 https://doi.org/10.3181/00379727-118-29995

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Implication

Norepinephrine may indirectly modulate myocardial FFA oxidation in dogs; hypothesis-generating for human cardiac metabolism and should not change practice.

Effect of Norepinephrine on Myocardial Free Fatty Acid Uptake and Oxidation,

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of Norepinephrine on Myocardial Free Fatty Acid Uptake and Oxidation,

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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