Population
Open-chest dogs
Comparison
Partial coronary artery occlusion for 120 minutes vs Control (non-ischemic myocardium)
Design
Preclinical
Follow-up
120 minutes
Authors
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NEFA does not drive early ischemic dysfunction; animal data leave open its role only in prolonged severe hypoperfusion.
Early ischemic changes in mechanical function and metabolism are not caused by increased NEFA content, which accumulates later during prolonged ischemia.
Prinzen et al. (1984) studied this question.
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