Key result
Acetylcholine and vagal stimulation decreased segmental shortening during beta-adrenergic stimulation (-23% with dobutamine, -30% with amrinone) independently of nitric oxide.
Why the study?
Does nitric oxide mediate the cholinergic modulation of myocardial contractility in vivo?
Population
34 anesthetized, open-chest dogs with left anterior descending coronary artery perfused via an…
Comparison
Intracoronary infusion of acetylcholine… vs Baseline conditions and stimulation with…
Design
Preclinical
Authors
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Challenges NO mediation of cholinergic negative inotropy during beta-stimulation; leaves open human relevance from this animal model.
Does nitric oxide mediate the cholinergic modulation of myocardial contractility in vivo?
Acetylcholine and vagal stimulation exert a negative inotropic effect during beta-adrenergic stimulation that is independent of nitric oxide.
Crystal et al. (2001) studied this question. Acetylcholine (ACh) and vagal stimulation vs. Baseline / L-NAME was evaluated on Segmental shortening (SS). Acetylcholine and vagal stimulation decreased segmental shortening during beta-adrenergic stimulation (-23% with dobutamine, -30% with amrinone) independently of nitric oxide.
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