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June 1, 1991AJP Regulatory Integrative and Comparative Physiology

Bradykinin increases myocardial contractility: relation to the Gregg phenomenon

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Why the study?

Does bradykinin alter myocardial shortening in open-chest dogs?

Population

Open-chest dogs

Comparison

Bradykinin injected into the left anterior… vs Control circumflex regions

Design

Preclinical

Follow-up

Acute (15-20 seconds after injection)

Authors

PMP. A. MunchUniversity of California, DavisJLJohn C. LonghurstPreventive Cardiology

Discussion

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Implication

May enhance regional shortening via coronary flow in canine models; leaves open translation to human ventricular mechanics.

Structured PICO

Does bradykinin alter myocardial shortening in open-chest dogs?

P
Population
Open-chest dogs
I
Intervention
Bradykinin (1-10 micrograms) injected into the left anterior descending (LAD) coronary artery
C
Comparator
Control circumflex regions
O
Outcome
Wall motion (maximum end-diastolic and minimum end-systolic segment lengths, maximum shortening fraction) in LAD and circumflex regionssurrogate

Bradykinin increases regional myocardial shortening by enhancing coronary flow (Gregg phenomenon) and altering global ventricular function through systemic hypotension.

Cite This Study

Munch et al. (1991) studied this question.

synapsesocial.com/papers/6a77c27f137c7dcc81be0bdfhttps://doi.org/10.1152/ajpregu.1991.260.6.r1095
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regional myocardial effects of intracoronary bradykinin in conscious dogs1997 · 8 citations
  2. 2Bradykinin Degradation and Relation to Myocyte Contractility2000 · 1 citations
  3. 3Intracoronary infusion of bradykinin: effects on noradrenaline overflow following reperfusion of ischemic myocardium in the anesthetized dog1994 · 11 citations
  4. 4Analysis of responses to bradykinin in the pulmonary vascular bed of the cat1994 · 25 citations
  5. 5Effects of Bradykinin on Cardiovascular Remodeling in Renovascular Hypertensive Rats2004 · 32 citations