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December 1, 2000Journal of Cardiovascular Pharmacology and Therapeutics

Bradykinin Degradation and Relation to Myocyte Contractility

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Population

isolated adult porcine (n = 15) left ventricular (LV) myocyte preparations

Comparison

bradykinin (10 mol/L), BK() (10 mol/L), and… vs basal state (absence of BK, BK(), and ACE…

Design

Preclinical

Authors

RKR. Stephen KrombachMedical University of South CarolinaJMJames H. McElmurayMedical University of South CarolinaDGDavid M. GayBrigham Young University

Discussion

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Implication

Should not change clinical practice; leaves open whether bradykinin effects on myocytes translate in vivo.

Structured PICO

P
Population
isolated adult porcine (n = 15) left ventricular (LV) myocyte preparations
I
Intervention
bradykinin (BK) (10(-8) mol/L), BK((1-7)) (10(-8) mol/L), and pretreatment by ACE inhibition (benazaprilat)
C
Comparator
basal state (absence of BK, BK((1-7)), and ACE inhibition)
O
Outcome
myocyte contractility (velocity of shortening)surrogate

Bradykinin directly reduces left ventricular myocyte contractility, an effect that is partially mediated by its degradation and can be blunted by ACE inhibition.

Cite This Study

Krombach et al. (2000) studied this question.

synapsesocial.com/papers/6a77c27d137c7dcc81be0bcfhttps://doi.org/10.1054/jcpt.2000.16694
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relative effects of alpha 1-adrenoceptor blockade, converting enzyme inhibitor therapy, and angiotensin II subtype 1 receptor blockade on ventricular remodeling in the dog.1994 · 107 citations
  2. 2Relation between ventricular and myocyte function with tachycardia-induced cardiomyopathy.1992 · 121 citations
  3. 3Effects of chronic supraventricular pacing tachycardia on relaxation rate in isolated cardiac muscle cells1995 · 27 citations
  4. 4Contractile and cytoskeletal content, structure, and mRNA levels with tachycardia-induced cardiomyopathy1995 · 53 citations
  5. 5Role of bradykinin-NO pathway in prevention of cardiac hypertrophy by ACE inhibitor in rat cardiomyocytes1997 · 72 citations