Haemodynamic and cardiac effects of kinin B₁ and B₂ receptor stimulation in conscious instrumented dogs

Conscious mongrel dogs chronically instrumented with an intra-aortic catheter, a Königsberg intraventricular pressure transducer and a Döppler flow probe around the left coronary artery, after ganglionic blockade with hexamethonium.

Bradykinin B1 and B2 receptor agonists (des-Arg9-bradykinin and bradykinin [BK], 1 microgram kg-1 min-1 as a 2 min i.v. infusion), with and without specific antagonists (des-Arg9-[Leu8]-BK, Hoe 140), NO synthase inhibitor (L-NOARG), and prostanoid synthesis inhibitor (indomethacin).

Baseline or absence of specific antagonists/inhibitors.

Changes in mean arterial pressure (MAP) and coronary vascular resistance (CVR).surrogate