Key result
In the pulmonary vascular bed of the cat, bradykinin caused dose-related decreases in lobar arterial pressure, mediated in part by B2-receptors, nitric oxide release, and cGMP levels.
Population
Pulmonary vascular bed of the cat
Comparison
Bradykinin (BK) administration vs Baseline responses to BK without…
Design
Preclinical
Authors
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Should not guide clinical pulmonary hypertension management; leaves open B2-NO pathway translation to human disease.
Bradykinin induces vasodilation in the feline pulmonary vascular bed via B2-receptor activation and nitric oxide release.
DeWitt et al. (1994) studied this question. Bradykinin was evaluated on Lobar arterial pressure and vasodilator responses. In the pulmonary vascular bed of the cat, bradykinin caused dose-related decreases in lobar arterial pressure, mediated in part by B2-receptors, nitric oxide release, and cGMP levels.
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