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June 9, 2015AJP Heart and Circulatory Physiology

Analysis of erectile responses to bradykinin in the anesthetized rat

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Population

Anesthetized rats

Design

Preclinical

Authors

JEJustin A. EdwardSt. Francis HospitalEPEdward A. PankeyTulane UniversityRJRyan C. JupiterTulane University

Discussion

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Implication

Hypothesis-generating for bradykinin in erectile physiology; leaves open human clinical relevance.

Structured PICO

P
Population
Anesthetized rats
I
Intervention
Intracorporal injections of bradykinin (1-100 μg/kg)
O
Outcome
Intracavernosal pressure (ICP) and mean arterial pressure (MAP)surrogate

Erectile responses to bradykinin in rats are mediated by kinin B2 receptors and cyclooxygenase products, independent of the nitric oxide pathway.

Cite This Study

Edward et al. (2015) studied this question.

synapsesocial.com/papers/6a22e8ded72a377c8660cabchttps://doi.org/10.1152/ajpheart.00765.2014
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Also Consider

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  1. 1Antihypertensive actions of angiotensin-(1-7) in spontaneously hypertensive rats1995 · 225 citations
  2. 2Potentiation of Bradykinin by Angiotensin-(1-7) on Arterioles of Spontaneously Hypertensive Rats Studied In Vivo2001 · 122 citations
  3. 3Angiotensin(1–7) potentiates bradykinin-induced vasodilatation in man2001 · 73 citations
  4. 4Potentiation of the Hypotensive Effect of Bradykinin by Short-term Infusion of Angiotensin-(1-7) in Normotensive and Hypertensive Rats1997 · 80 citations
  5. 5Vasodilator responses to acetylcholine are not mediated by the activation of soluble guanylate cyclase or TRPV4 channels in the rat2014 · 13 citations