What question did this study set out to answer?

To determine whether bradykinin B2 receptors mediate the reflex pressor and cardiovascular responses elicited by selective intrarenal bradykinin administration.

September 1, 1999Canadian Journal of Physiology and Pharmacology

Intrarenal infusion of bradykinin elicits a pressor response in conscious rats via a B2-receptor mechanism

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Authors

KHKimberly M. HoaglandAmgen (United States)DMDavid A. MaddoxUniversity of South Dakota DMDouglas S. MartinUniversity of Aberdeen

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Implication

Experimental study demonstrates that intrarenal bradykinin increases arterial pressure and heart rate via B2 receptors in conscious rats, indicating neurogenic reflex regulation of blood pressure.

Key Points

To determine whether bradykinin B2 receptors mediate the reflex pressor and cardiovascular responses elicited by selective intrarenal bradykinin administration.
Conscious, unrestrained rats were instrumented with Doppler flow probes on the left renal artery, an intrarenal catheter, and a femoral arterial line to record mean arterial pressure (MAP), heart rate (HR), and renal blood flow (RBF).
Cumulative five-point dose-response infusions of bradykinin (5–80 µg·kg⁻¹·min⁻¹) were administered before and after autonomic ganglionic blockade or selective B2-receptor antagonism with HOE-140 (50 µg/kg bolus).
Intrarenal bradykinin infusion produced dose-dependent increases in MAP (maximum: 26 ± 3 mmHg), HR (maximum: 130 ± 18 beats/min), and RBF (maximum: 28% increase).
Autonomic ganglionic blockade abolished bradykinin-evoked increases in MAP (maximum: -6 ± 5 mmHg), HR (maximum: 31 ± 14 beats/min), and RBF (maximum: 7 ± 2%).
Selective intrarenal B2-receptor blockade with HOE-140 eliminated the pressor response (MAP: -2 ± 3 mmHg) and tachycardia (HR: 15 ± 11 beats/min), while causing a 22% reduction in RBF at the highest bradykinin dose.

Cite This Study

Hoagland et al. (1999) studied this question.

synapsesocial.com/papers/6a8afd2552e1a91077e9547a https://doi.org/10.1139/y99-054

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Implication

Experimental study demonstrates that intrarenal bradykinin increases arterial pressure and heart rate via B2 receptors in conscious rats, indicating neurogenic reflex regulation of blood pressure.

Intrarenal infusion of bradykinin elicits a pressor response in conscious rats via a B2-receptor mechanism

Discussion

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Implication

Key Points

Cite This Study

Intrarenal infusion of bradykinin elicits a pressor response in conscious rats via a B2-receptor mechanism

Discussion

Member takes

Implication

Key Points

Cite This Study

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