June 16, 2009The Journal of PhysiologyOpen Access

Differential action of bradykinin on intrarenal regional perfusion in the rat: waning effect in the cortex and major impact in the medulla

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Population

Anaesthetized rats

Design

Preclinical

Authors

BBBożena BądzyńskaMossakowski Medical Research Institute, Polish Academy of Sciences JSJanusz SadowskiInstitute of Clinical and Experimental Medicine

Discussion

Member takes

Implication

Hypothesis-generating for bradykinin-NO-KCa medullary perfusion in animals; leaves open translation to human renal hemodynamics.

Structured PICO

Population

Anaesthetized rats

Intervention

Bradykinin (Bk) infused into renal artery (0.3-0.6 mg kg(-1) h(-1)), renal cortex (0.75-1.5 mg kg(-1) h(-1)), or medulla (0.3 mg kg(-1) h(-1)), with or without pre-treatment with L-NAME, 1-aminobenzotriazole, or clotrimazole

Outcome

Perfusion of whole kidney (RBF) and of the cortex, outer- and inner medulla (CBF, OMBF, IMBF)surrogate

Bradykinin selectively increases perfusion of the renal medulla, especially the inner layer, via activation of the NO system and calcium-dependent K+ channels, while its cortical vasodilatation effect is only transient.

Cite This Study

Bądzyńska et al. (2009) studied this question.

synapsesocial.com/papers/6a7bfeb7351d91d38cc6468f https://doi.org/10.1113/jphysiol.2009.172007

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Differential action of bradykinin on intrarenal regional perfusion in the rat: waning effect in the cortex and major impact in the medulla

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differential action of bradykinin on intrarenal regional perfusion in the rat: waning effect in the cortex and major impact in the medulla

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider