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December 1, 1995AJP Heart and Circulatory Physiology

cGMP elevation does not mediate muscarinic agonist-induced negative inotropy in rat ventricular cardiomyocytes

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Population

Electrically stimulated rat ventricular cardiomyocytes

Comparison

Acetylcholine, carbachol, or sodium… vs Isoproterenol alone (implied)

Design

Preclinical

Follow-up

2 min

Authors

KMKaren L. MacDonellCollege of Physicians and Surgeons of OntarioGTGlen F. TibbitsPediatric CardiologyJDJ. DiamondInternational Monetary Fund

Discussion

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Implication

Indicates cGMP-independent negative inotropy by muscarinic agonists in beta-stimulated rat myocytes; leaves open the pathway and human relevance.

Structured PICO

P
Population
Electrically stimulated rat ventricular cardiomyocytes
I
Intervention
Acetylcholine (1 and 10 microM), carbachol (1 and 10 microM), or sodium nitroprusside (SNP) (10 and 100 microM) in the presence of 1 nM isoproterenol
C
Comparator
Isoproterenol alone (implied)
O
Outcome
Changes in contractility (magnitude of cell shortening, contraction and relaxation rates) and levels of cGMP and cAMPsurrogate

The negative inotropic effects of muscarinic agonists in isoproterenol-stimulated rat ventricular cardiomyocytes are not mediated by alterations in cGMP or cAMP levels.

Cite This Study

MacDonell et al. (1995) studied this question.

synapsesocial.com/papers/6a922cf65ab1441fe3c8019dhttps://doi.org/10.1152/ajpheart.1995.269.6.h1905
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cyclic GMP‐dependent protein kinase activation in the absence of negative inotropic effects in the rat ventricle1997 · 16 citations
  2. 2Lack of Second Messenger Function of Cyclic GMP in Acetylcholine-Induced Negative Inotropism1986 · 12 citations
  3. 3Elevation of Guanosine 3′,5′-Cyclic Phosphate in Rat Heart after Perfusion with Acetylcholine1970 · 454 citations
  4. 4Cyclic AMP‐dependent inotropic effects are differentially regulated by muscarinic Gi‐dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle2010 · 5 citations
  5. 5Muscarinic receptor stimulation and cyclic AMP‐dependent effects in guinea‐pig ventricular myocardium1990 · 11 citations