December 1, 1997British Journal of PharmacologyOpen Access

Cyclic GMP‐dependent protein kinase activation in the absence of negative inotropic effects in the rat ventricle

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Population

Rat intact ventricular preparations and freshly isolated ventricular cardiomyocytes

Design

Preclinical

Authors

KMKaren L. MacDonellCollege of Physicians and Surgeons of Ontario JDJack DiamondCenter for Inquiry

Discussion

Member takes

Implication

Challenges cGMP/PKG mediation of muscarinic negative inotropy in rats; leaves open translation to human ventricular function.

Structured PICO

Population

Rat intact ventricular preparations and freshly isolated ventricular cardiomyocytes

Intervention

Carbachol, sodium nitroprusside (SNP), and atrial natriuretic peptide (ANP) in the presence of isoproterenol

Outcome

Contractility, cyclic GMP content, and PKG activitysurrogate

The study demonstrates that cyclic GMP and PKG activation are not required for the negative inotropic effects of muscarinic receptor agonists in rat ventricles.

Cite This Study

MacDonell et al. (1997) studied this question.

synapsesocial.com/papers/6a85abaaee60e6e86dae69e2 https://doi.org/10.1038/sj.bjp.0701492

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Cyclic GMP‐dependent protein kinase activation in the absence of negative inotropic effects in the rat ventricle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cyclic GMP‐dependent protein kinase activation in the absence of negative inotropic effects in the rat ventricle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider