Key result
SG-75 induced a selective negative inotropic effect and produced a uniform depression of developed tension at all frequencies tested in isolated canine atrial preparations.
Population
Isolated blood-perfused canine atrial preparations
Comparison
SG-75 administered via the cannulated sinus node… vs 1-verapamil
Design
Preclinical
Authors
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Supports exploration of frequency-independent negative inotropy for anti-anginal therapy; leaves open clinical translation from canine models.
SG-75 exhibits a selective negative inotropic effect in isolated canine atria, differing from the frequency-dependent effects of verapamil.
Chiba et al. (1980) studied this question. SG-75 (2-nicotinamidoethyl nitrate) vs. 1-verapamil was evaluated on Chronotropic and inotropic effects. SG-75 induced a selective negative inotropic effect and produced a uniform depression of developed tension at all frequencies tested in isolated canine atrial preparations.
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