Key result
Nicorandil produced a negative inotropic effect and elevated cyclic GMP in isolated canine atria, but unlike carbachol, its effect was counteracted by isoproterenol without decreasing cyclic AMP.
Why the study?
Does nicorandil affect the force of contraction and cyclic nucleotide levels differently than carbachol in isolated canine right atria?
Population
Isolated canine right atria
Comparison
Nicorandil and its interaction with isoproterenol vs Carbachol (muscarinic receptor stimulation)
Design
Preclinical
Authors
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Nicorandil's atrial effects in dogs warrant no clinical extrapolation; leaves open mechanistic distinctions from muscarinic agonists for human study.
Does nicorandil affect the force of contraction and cyclic nucleotide levels differently than carbachol in isolated canine right atria?
Nicorandil mimics the cyclic GMP elevation but not the cyclic AMP reduction seen with muscarinic receptor stimulation in canine atria.
Endoh et al. (1983) studied this question. Nicorandil vs. Carbachol was evaluated on Force of contraction and cyclic nucleotide levels (cyclic GMP and cyclic AMP). Nicorandil produced a negative inotropic effect and elevated cyclic GMP in isolated canine atria, but unlike carbachol, its effect was counteracted by isoproterenol without decreasing cyclic AMP.
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