Why the study?
Does nicorandil improve hemodynamic and hormonal parameters in a canine model of acute ischemic heart failure compared to cromakalim and nitroglycerin?
Population
Canine model of acute ischemic heart failure induced by coronary embolization
Comparison
Nicorandil vs Cromakalim and Nitroglycerin
Design
Preclinical
Follow-up
20 min for each dosing
Authors
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May support nicorandil evaluation in acute ischemic HF; leaves open translation from canine models to humans.
Does nicorandil improve hemodynamic and hormonal parameters in a canine model of acute ischemic heart failure compared to cromakalim and nitroglycerin?
In a canine model of acute ischemic heart failure, nicorandil effectively reduced both preload and afterload and improved cardiac contractility, suggesting potential utility in treating acute ischemic heart failure.
Kamijo et al. (1999) studied this question.
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