Why the study?
Does nicorandil improve coronary artery diameter and blood flow in anesthetized dogs with coronary spasm, and is this effect modified by glibenclamide?
Population
Anesthetized dogs with coronary spasm induced by intracoronary U 46619 (a thromboxane A2 mimetic)
Comparison
Intracoronary nicorandil, cromakalim, or… vs Intravenous glibenclamide versus no glibenclamide
Design
Preclinical
Authors
Loading...
Supports nitrate-like action of nicorandil on conductive vessels in dogs; leaves open human translation and clinical relevance.
Does nicorandil improve coronary artery diameter and blood flow in anesthetized dogs with coronary spasm, and is this effect modified by glibenclamide?
The spasmolytic effect of nicorandil on canine conductive coronary vessels is likely mediated by a nitroglycerin-like action rather than K-channel opening, whereas its dilation of resistive vessels is largely due to K-channel opening.
Imagawa et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: