Why the study?
Does nicorandil improve hemodynamic parameters compared to nitroglycerin and cromakalim in a canine model of acute congestive heart failure?
Does nicorandil improve hemodynamic parameters compared to nitroglycerin and cromakalim in a canine model of acute congestive heart failure?
Nicorandil exerts beneficial hemodynamic effects in experimental acute heart failure by reducing both preload and afterload.
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Nicorandil's balanced hemodynamic effects in canine acute HF warrant human trials; should not yet change clinical practice.
Noguchi et al. (1998) studied this question.
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