Key result
Oral nicorandil 10 mg three times daily for 4 weeks significantly improved LV diastolic function in patients with HCM, increasing LV peak early filling velocity from 0.51 to 0.59 m/sec (p<0.01).
Why the study?
Does nicorandil improve left ventricular systolic and diastolic function in symptomatic patients with hypertrophic cardiomyopathy?
Observational (n=12)
Does nicorandil improve left ventricular systolic and diastolic function in symptomatic patients with hypertrophic cardiomyopathy?
Absolute Event Rate: 0.59% vs 0.51%
p-value: p=<0.01
Oral nicorandil improves left ventricular diastolic function in symptomatic patients with hypertrophic cardiomyopathy, potentially by ameliorating subendocardial ischemia.
No takes yet. Share an insight, caveat, or question.
May support nicorandil for diastolic function in HCM; hypothesis-generating and should not change practice without RCTs.
Suwa et al. (1995) conducted an observational in Hypertrophic cardiomyopathy (n=12). Nicorandil vs. Baseline was evaluated on Left ventricular peak early filling velocity (m/sec) (p=<0.01). Oral nicorandil 10 mg three times daily for 4 weeks significantly improved LV diastolic function in patients with HCM, increasing LV peak early filling velocity from 0.51 to 0.59 m/sec (p<0.01).
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