Effects of 2-nicotinamidoethyl nitrate (nicorandil) on hemodynamic responses to supine bicycle ergometer exercise in patients with prior myocardial infarction.

12 patients with prior myocardial infarction (mean age 52.1, 11 male). Patients with angina pectoris were excluded.

Nicorandil 15 mg single oral administration

Baseline measurements before nicorandil administration (self-controlled)

Hemodynamic responses (cardiac index, stroke volume index, blood pressure, systemic vascular resistance, pulmonary capillary wedge pressure, coronary sinus blood flow, coronary vascular resistance) during supine bicycle ergometer exercise testing at 60 minutes post-dosesurrogate