Why the study?
Does nicorandil infused into the pulmonary artery alter hemodynamic parameters in patients with coronary artery disease and normal controls?
Population
17 patients undergoing cardiac catheterization for investigation of chest pain
Comparison
Nicorandil infused into the pulmonary artery at… vs Baseline measurements prior to infusion, and…
Design
Cohort
Follow-up
20 minutes
Authors
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May support pulmonary artery nicorandil for sustained preload reduction in CAD; leaves open randomized confirmation of clinical benefit.
Does nicorandil infused into the pulmonary artery alter hemodynamic parameters in patients with coronary artery disease and normal controls?
Nicorandil infusion into the pulmonary artery produces a sustained reduction in preload and a transient reduction in afterload, with additive effects in patients already on antianginal medication.
Choi et al. (2001) studied this question.
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