Key result
Nicorandil produced greater decreases in aortic and left ventricular systolic pressure and increased cardiac output and coronary blood flow compared to nitroglycerin in conscious dogs.
Why the study?
Does nicorandil produce different hemodynamic effects compared to nitroglycerin in conscious dogs?
Population
Conscious dogs
Comparison
Nicorandil infusion before and after… vs Nitroglycerin infusion (5-60 micrograms/kg/min)
Design
Preclinical
Authors
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May guide vasodilator research in ischemia; leaves open translation from canine hemodynamics to patients.
Does nicorandil produce different hemodynamic effects compared to nitroglycerin in conscious dogs?
Nicorandil and nitroglycerin have varying hemodynamic spectra, with nicorandil uniquely increasing coronary blood flow and cardiac output in conscious dogs.
Preuss et al. (1985) studied this question. Nicorandil vs. Nitroglycerin (5-60 micrograms/kg/min) was evaluated on Hemodynamic effects including heart rate, aortic and left ventricular pressures, cardiac output, and coronary blood flow. Nicorandil produced greater decreases in aortic and left ventricular systolic pressure and increased cardiac output and coronary blood flow compared to nitroglycerin in conscious dogs.
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