Key result
Intracoronary nicorandil triples coronary blood flow without adverse mechanical or electrical effects in preclinical testing.
Why the study?
The effective and safe dosage for intracoronary administration of nicorandil in dogs was not established.
Does intracoronary nicorandil improve coronary blood flow without adverse mechanical or electrical effects in a canine model of normal and ischaemic myocardium?
Population
10 mongrel dogs of either sex weighing 14.6-20.5 kg
Comparison
Intracoronary infusion of nicorandil (0.025, 0.25, 1.0, or 2.5 mg) vs saline
Design
Preclinical study with normoxic and ischaemic groups
Authors
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Hypothesis-generating for intracoronary nicorandil; human trials required before clinical translation.
Does intracoronary nicorandil improve coronary blood flow without adverse mechanical or electrical effects in a canine model of normal and ischaemic myocardium?
p-value: p=<0.05
Intracoronary nicorandil at 0.25 mg effectively induces coronary vasodilation without deleterious mechanical or electrical effects in dogs, whereas higher doses cause myocardial depression and arrhythmias.
Kojima et al. (1990) studied Myocardial ischaemia (experimental) (n=10). Nicorandil vs. Saline without nicorandil was evaluated on LAD blood flow and regional myocardial contraction (p=<0.05). Intracoronary administration of 0.25 mg of nicorandil effectively increased coronary blood flow (from 28.4 to 86.3 ml/min, p<0.05) without deleterious mechanical or electrical effects in dogs.
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