Why the study?
Does intravenous nicorandil improve the recovery of regional myocardial contractile function after coronary artery occlusion and reperfusion in conscious dogs?
Population
Chronically instrumented conscious dogs subjected to a 10-minute coronary artery occlusion
Comparison
Intravenous administration of nicorandil vs Control group
Design
Preclinical
Follow-up
Throughout the reperfusion period
Authors
Loading...
Supports further nicorandil study in reperfusion; leaves open clinical translation from this canine model.
Does intravenous nicorandil improve the recovery of regional myocardial contractile function after coronary artery occlusion and reperfusion in conscious dogs?
Intravenous nicorandil protects ischemic cardiac tissue and enhances the recovery of myocardial contractile function following ischemia-reperfusion in a canine model.
Shimshak et al. (1986) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: