Key result
Nicorandil significantly reduced the incidence of ventricular tachyarrhythmia induced during ischaemia by augmenting epicardial muscle inactivation via sarcolemmal K(ATP) channel activation.
Why the study?
Does nicorandil prevent ventricular tachyarrhythmia during acute myocardial ischaemia in isolated canine left ventricular wedges?
Population
Isolated arterially perfused canine left ventricular wedges subjected to acute myocardial ischaemia
Comparison
Nicorandil vs Absence of nicorandil
Design
Preclinical
Authors
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Does not support clinical use in ischaemia; leaves open human translation of antiarrhythmic effects.
Does nicorandil prevent ventricular tachyarrhythmia during acute myocardial ischaemia in isolated canine left ventricular wedges?
Nicorandil prevents ventricular tachyarrhythmia during acute global ischaemia primarily by augmenting the inactivation of epicardial muscle through the activation of sarcolemmal K(ATP) channels.
Hirose et al. (2008) studied Acute myocardial ischaemia. Nicorandil vs. Control / HMR1098 was evaluated on Incidence of ventricular tachyarrhythmia (VT) induced during ischaemia. Nicorandil significantly reduced the incidence of ventricular tachyarrhythmia induced during ischaemia by augmenting epicardial muscle inactivation via sarcolemmal K(ATP) channel activation.
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