Population
Langendorff-perfused rabbit hearts 4-5 hours after coronary artery ligation and control hearts
Comparison
Nicorandil (100 μM) administration vs Control hearts and baseline measurements
Design
Preclinical
Authors
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May suppress post-MI arrhythmias via alternans reduction; hypothesis-generating in rabbit models, clinical trials needed before any practice change.
In a rabbit model of phase-2 myocardial infarction, nicorandil suppresses spatially discordant alternans and ameliorates proarrhythmic effects despite down-regulation of K(ATP) channels.
LEE et al. (2012) studied this question.
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