June 1, 1991Cardiovascular Research
Nicorandil suppresses early afterdepolarisation and ventricular arrhythmias induced by caesium chloride in rabbits in vivo
Why the study?
Does nicorandil suppress early afterdepolarisations and ventricular arrhythmias induced by caesium chloride in rabbits in vivo?
Structured PICO
Does nicorandil suppress early afterdepolarisations and ventricular arrhythmias induced by caesium chloride in rabbits in vivo?
P
Population
15 rabbits in vivo
I
Intervention
Intravenous infusion of nicorandil (0.2 mg.kg-1) prior to intravenous bolus injections of caesium chloride (1 mmol.kg-1 given three times at 20 min intervals)
C
Comparator
Caesium chloride alone (control group)
O
Outcome
Amplitude of early afterdepolarisations and incidence of ventricular tachycardias over 60 minsurrogate
Nicorandil suppresses early afterdepolarisations and ventricular tachyarrhythmias induced by caesium chloride in an in vivo rabbit model, likely by increasing membrane potassium conductance.
Authors
Discussion
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Implication
Supports nicorandil investigation in arrhythmia models; leaves open translation to human ventricular tachyarrhythmia prevention.
Cite This Study
Takahashi et al. (1991) studied this question.