Why the study?
Does nicorandil prevent the decrease in baroreflex sensitivity following transient global cerebral ischaemia in dogs?
Population
Canine model of 5 min global cerebral ischaemia produced by occlusion of the left subclavian and the…
Comparison
Nicorandil infused for 60 min just before… vs Nitroglycerin or nicardipine infused for 60 min…
Design
Preclinical
Authors
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Preclinical data on nicorandil in canine cerebral ischaemia warrant translational studies; leaves open any human clinical relevance.
Does nicorandil prevent the decrease in baroreflex sensitivity following transient global cerebral ischaemia in dogs?
Nicorandil and nitroglycerin, but not nicardipine, protect against the dysfunction of the central vagal baroreflex system following transient global cerebral ischaemia in dogs.
Kurihara et al. (1993) studied this question.
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