September 1, 1993Clinical and Experimental Pharmacology and Physiology

Effect of Nicorandil on Post‐ischaemic Contractile Dysfunction in the Heart: Roles of Its Atp‐sensitive K’ Channel Opening Property and Nitrate Property

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Why the study?

Does nicorandil improve post-ischaemic contractile dysfunction in a rabbit model of myocardial stunning?

Population

Open-chest anaesthetized rabbits with myocardial stunning induced by 10 min of coronary occlusion followed…

Comparison

Nicorandil administered during pre-ischaemic and… vs Untreated controls, or nitroglycerin

Design

Preclinical

Follow-up

30 min of reperfusion

Authors

TIToshihiro IwamotoJapan Atomic Energy Agency TMTetsuji MiuraHeart Failure / Cardiomyopathy KUKazuyuki UrabeTenshi Hospital

Discussion

Member takes

Implication

Nicorandil may protect against stunning via KATP in rabbits; extends experimental data but leaves open clinical translation.

Structured PICO

Does nicorandil improve post-ischaemic contractile dysfunction in a rabbit model of myocardial stunning?

Population

Open-chest anaesthetized rabbits with myocardial stunning induced by 10 min of coronary occlusion followed by 30 min of reperfusion

Intervention

Nicorandil (10 micrograms/kg per min) administered during pre-ischaemic and post-ischaemic periods, or restricted to a pre-ischaemic 10 min period

Comparator

Untreated controls, or nitroglycerin (1 micrograms/kg per min)

Outcome

Systolic thickening fraction (TF) at 30 min after reperfusionsurrogate

Nicorandil protects against myocardial stunning via KATP channel opening when given before ischaemia, and its nitrate property may contribute during reperfusion.

Cite This Study

Iwamoto et al. (1993) studied this question.

synapsesocial.com/papers/6a853fdee3de713998f246cf https://doi.org/10.1111/j.1440-1681.1993.tb01746.x

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Effect of Nicorandil on Post‐ischaemic Contractile Dysfunction in the Heart: Roles of Its Atp‐sensitive K’ Channel Opening Property and Nitrate Property

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of Nicorandil on Post‐ischaemic Contractile Dysfunction in the Heart: Roles of Its Atp‐sensitive K’ Channel Opening Property and Nitrate Property

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider