Why the study?
Does long-term oral nicorandil improve cardiac sympathetic nerve activity in patients with first acute myocardial infarction after primary coronary angioplasty?
Population
40 patients with their first acute myocardial infarction who were treated with intravenous nicorandil before…
Comparison
Oral nicorandil added to standard therapy vs Placebo added to standard therapy
Design
RCT, randomized
Follow-up
6 months
Authors
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Supports long-term oral nicorandil after primary angioplasty for first AMI; extends acute IV data to chronic sympathetic modulation in RCT.
Does long-term oral nicorandil improve cardiac sympathetic nerve activity in patients with first acute myocardial infarction after primary coronary angioplasty?
Long-term oral nicorandil therapy following primary angioplasty for first AMI significantly improves cardiac sympathetic nerve activity compared to short-term intravenous therapy alone.
Kasama et al. (2007) studied this question.
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