Why the study?
Does nicorandil improve myocardial microcirculation and cardiac function compared to isosorbide dinitrate in patients with acute myocardial infarction undergoing direct balloon angioplasty?
Population
60 patients with acute myocardial infarction in Killip class I undergoing reperfusion treatment by direct…
Comparison
Nicorandil infused intravenously at 6 mg/h for… vs Isosorbide dinitrate infused intravenously at 6…
Design
RCT, randomised, Double blind
Follow-up
3 weeks
Authors
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Supports nicorandil over ISDN for ST recovery after AMI reperfusion; extends RCT evidence for microcirculatory benefit in primary angioplasty.
Does nicorandil improve myocardial microcirculation and cardiac function compared to isosorbide dinitrate in patients with acute myocardial infarction undergoing direct balloon angioplasty?
Nicorandil as an adjunct to direct balloon angioplasty in AMI improves myocardial microcirculation and regional wall motion more effectively than isosorbide dinitrate.
Nahoko Ikeda (2004) studied this question.
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