Population
Canine right atrial muscle
Comparison
Nicorandil vs Pinacidil, cromakalim, nifedipine, and sodium…
Design
Preclinical
Authors
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May inform experimental nicorandil use in atrial models; leaves open translation of K-channel effects to human myocardium.
The negative inotropic effect of nicorandil in canine atrial muscle is mediated by potassium channel opening rather than cyclic GMP accumulation.
Yanagisawa et al. (1988) studied this question.
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