Population
Canine atrial muscles
Comparison
Isoproterenol in the presence of carbachol or… vs Carbachol or nicorandil alone
Design
Preclinical
Authors
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Differential modulation in canine atria supports mechanistic hypotheses on autonomic effects; leaves open translation to human arrhythmias.
Isoproterenol differentially modulates the plateau duration of canine atrial action potentials depending on the presence of carbachol versus nicorandil, likely reflecting changes in the slow inward current.
Iijima et al. (1987) studied this question.
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