August 1, 1985AJP Heart and Circulatory Physiology

Attenuation of muscarinic cholinergic inhibition by islet-activating protein in the heart

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Population

Isolated atria from rats

Design

Preclinical

Authors

MEMakoto EndohYamagata Prefectural Central Hospital MMMichihiro MaruyamaChiba University TIToshio IijimaTohoku University

Discussion

Member takes

Implication

Does not inform clinical cholinergic modulation; hypothesis-generating for muscarinic cGMP pathways in cardiac tissue.

Structured PICO

Population

Isolated atria from rats

Intervention

Intravenous islet-activating protein (IAP) (0.125-1.0 micrograms/100 g body wt) administered 12-72 hours prior to experiments

Outcome

Chronotropic and inotropic actions of carbachol, and tissue cAMP and cGMP levelssurrogate

Islet-activating protein (pertussis toxin) attenuates muscarinic cholinergic inhibition in the heart through both cAMP-dependent and cAMP-independent subcellular processes.

Cite This Study

Endoh et al. (1985) studied this question.

synapsesocial.com/papers/6a7d315e1e40f448689656c1 https://doi.org/10.1152/ajpheart.1985.249.2.h309

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Attenuation of muscarinic cholinergic inhibition by islet-activating protein in the heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Attenuation of muscarinic cholinergic inhibition by islet-activating protein in the heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider