Key result
Defining sex-based differences in valvular heart disease may improve disease recognition and treatment outcomes.
Why the study?
Large gaps remain in understanding sex-based differences across valvular heart disease, and defining sex-specific responses may improve disease recognition, treatment strategies, and outcomes.
Investigates sex differences affecting outcomes in valvular heart disease, suggesting implications for diagnosis and treatment.
Numerous sex-based differences are observed across the spectrum of valvular heart disease, starting with pathophysiology and progression of disease, moving on to compensation and comorbidities (both cardiovascular such as coronary artery disease and noncardiovascular such as frailty), assessment of severity and hemodynamics including timing of intervention, and procedural risks/benefits and outcomes. The aortic valve is perhaps best understood with sex differences in both pathologic changes and response to volume and pressure overload, yet large gaps in our understanding still exist. Studies of other valve diseases have focused on differences in prevalence, presentation, and outcomes for surgical or transcatheter therapies. Defining sex-specific responses to valvular heart disease may improve disease recognition, define treatment strategies, and improve outcomes.
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Hahn et al. (2022) conducted a review in Valvular heart disease. Sex-related factors was evaluated. Sex-based differences exist across the spectrum of valvular heart disease, and defining these sex-specific responses may improve disease recognition, treatment strategies, and outcomes.
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