Key result
Extracorporeal membrane oxygenation-assisted ablation successfully treated a 42-year-old man with extremely refractory Purkinje ventricular fibrillation requiring over 100 shocks.
Why the study?
Severe refractory Purkinje ventricular fibrillation is rare, with few multicenter reports available to inform prognosis and best practices.
Case Report (n=1)
No
Timely recognition and use of advanced hemodynamic support like ECMO can yield excellent outcomes in patients with extremely refractory Purkinje ventricular fibrillation undergoing ablation.
Supports emergency ablation consideration in refractory fascicular VF; leaves open optimal timing, support, and outcomes in larger cohorts.
BACKGROUND: Fascicular ventricular arrhythmias represent a spectrum of disease ranging from premature ventricular contraction, idiopathic ventricular tachycardia to idiopathic Purkinje ventricular fibrillation (VF). In the most severe cases, VF can become refractory to many therapies and require emergency ablation with hemodynamic support. CASE SUMMARY: We present a case of a 42-year-old man with no significant past medical history who presented with refractory VF that required over 100 shocks and eventual extracorporeal membrane oxygenation-assisted ablation. DISCUSSION: Extreme presentations of Purkinje VF are rare with few multicenter reports in the literature informing prognosis and best practices. This pathophysiology is postulated to involve the Purkinje-myocardial junction. TAKE-HOME MESSAGES: Timely recognition of refractory VF and the need for advanced hemodynamic support is critical for yielding a good outcome. This case highlights the importance of bystander cardiopulmonary resuscitation and highly coordinated care among specialties yielding many lessons learned and an excellent outcome.
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Alyesh et al. (2025) conducted a case report in Refractory Purkinje ventricular fibrillation (n=1). Extracorporeal membrane oxygenation-assisted ablation was evaluated on Clinical outcome. Extracorporeal membrane oxygenation-assisted ablation successfully treated a 42-year-old man with extremely refractory Purkinje ventricular fibrillation requiring over 100 shocks.
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