What question did this study set out to answer?

This research investigates whether prediabetic islets in obese rats have an increased lipogenic capacity contributing to NIDDM development.

March 1, 1997Diabetes

Increased Lipogenic Capacity of the Islets of Obese Rats: A Role in the Pathogenesis of NIDDM

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Randomized trial shows higher lipogenic capacity in prediabetic islets of obese rats, suggesting risk factors for NIDDM.

This research investigates whether prediabetic islets in obese rats have an increased lipogenic capacity contributing to NIDDM development.
Compared metabolism of long-chain fatty acids in pancreatic islets of obese prediabetic and nonprediabetic Zucker diabetic fatty rats and lean Wistar rats.
Measured triglyceride accumulation in response to free fatty acid exposure in vitro.
Assessed glycerol-3-phosphate acyl-transferase activity and mRNA levels in islets.
Obese prediabetic islets accumulated 7 to 15 times more triglycerides compared to lean islets exposed to the same free fatty acid concentrations.
Glycerol-3-phosphate acyl-transferase activity was found to be 12 times higher in obese rats' islets than in controls.
The mRNA expression of glycerol-3-phosphate acyl-transferase was significantly increased in islets of obese rats.

Lee et al. (1997) studied this question.

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